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Modafinil is usually called a "wakefulness-promoting agent." Researchers believe that this drug works by increasing the synaptic availability of neurotransmitters like monoamines, catecholamines, dopamine, serotonin, adenosine, and noradrenaline. Modafinil affects the hypothalamus, hippocampus, and amygdala which are parts of the brain.

Modafinil may be a tablet taken orally usually once-a-day.2 most of the people who work during the day take the drug within the morning on either a full or empty stomach. However, shift workers who take the drug to market wakefulness take the drug before their shifts begin.